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TTP, or thrombotic thrombocytopenic purpura, is a rare blood disorder that occurs when blood clots form in small blood vessels throughout the body. These clots can block the flow of oxygen-rich blood to various organs, leading to serious complications and even death if left untreated.

TTP is caused by a deficiency of an enzyme called ADAMTS13, which is responsible for breaking down large blood clots. Without sufficient ADAMTS13, clots can form in small blood vessels and cause a variety of symptoms, including:

  • Decreased platelet count (thrombocytopenia)
  • Red or purple bruising or rash on the skin (purpura)
  • Fatigue and weakness
  • Abdominal pain
  • Fever
  • Headache

The exact cause of TTP is not fully understood, but it is thought to be related to autoimmune disorders, certain medications, and infections. It can also occur as a result of other underlying medical conditions, such as cancer or HIV.

Diagnosis of TTP typically involves a combination of blood tests, imaging studies, and a medical history review. Treatment usually involves a combination of medications, such as plasma exchange therapy and anti-coagulants, to remove the clots and prevent new ones from forming. In severe cases, hospitalization may be necessary.

It’s important to seek medical attention if you experience any of the symptoms of TTP, as the condition can be life-threatening if left untreated. With prompt and appropriate treatment, the prognosis for TTP is generally good, and most people are able to make a full recovery.